Bioactive Small Molecules
AdipoGen OM173-alphaA (5 mg)
Chemical. CAS: 58286-56-9. Formula: C17H16O6. MW: 316.3. Isolated from Streptomyces sp. Antibiotic. Antimycoplasma. Antifungal compound. Anti-malarial agent. Ras-competitive non-CAAX mimetic type farnesyltransferase (FTase) inhibitor. Potential anticancer compound. Inducer of antiproliferative effects in tumor cell lines. Selective DNA (cytosine-5)-methyltransferase 3B (DNMT3B) inhibitor.
Medchemexpress LLC ML303 | 1638211-04-7 | 99.6% | 399.37 g·mol⁻1 | C21H16F3N3O2 | 25MG
ML303 is a pyrazolopyridine small-molecule antagonist of influenza virus nonstructural protein 1 (NS1), reported with an IC90 of 155 nM and an antiviral EC50 of 0.7 μM against Influenza A (H1N1). It is provided as a high-purity research compound intended for biochemical and cellular assays investigating NS1 function and viral replication.
- Pyrazolopyridine NS1 antagonist with reported IC90 155 nM and EC50 0.7 μM vs Influenza A (H1N1).
- Molecular formula C21H16F3N3O2 and molecular weight 399.37 g·mol⁻1.
- Purity 99.6%.
- Available as a powder in multiple small pack sizes for research use.
- Storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months).
- Intended for research use only; follow the safety data sheet for handling.
Medchemexpress LLC CP-724714 | 383432-38-0 | 98.7% | 469.55 | 25 MG
CP-724714 is a potent, selective, and orally active ErbB2 (HER2) tyrosine kinase inhibitor. It effectively inhibits ErbB2 receptor autophosphorylation in intact cells and demonstrates antitumor activities. With an IC50 of 10 nM for ErbB2, it shows significant selectivity against EGFR kinase.
- Potent and selective ErbB2 (HER2) tyrosine kinase inhibitor
- Orally active
- Inhibits ErbB2 receptor autophosphorylation
- Exhibits antitumor activities
- Induces G1 cell cycle block in ErbB2-overexpressing cells
- Demonstrates favorable nonclinical toxicity
Cayman Chemical ANTIBODY11-HETE 25ug
A non-enzymatically derived oxylipin; levels are increased in an in vitro model of lipid peroxidation induced by FAS in rat brain homogenates and in rat liver in an in vivo model of lipid peroxidation induced by CCl4; has been found in skin extracts from individuals with psoriasis and in atherosclerotic plaques
Medchemexpress LLC BCA-1/CXCL13 Mouse 20ug | 20ug
CXCL13 known as BCA-1 (B cell-attracting chemokine 1) or BLC (B-lymphocyte chemoattractant) is an efficacious attractant selective for B lymphocytes through binding to the BLR1/CXCR5 receptor[1] CXCL13 is a homeostatic chemokine and is constitutively secreted by stromal cells in B-cell areas of secondary lymphoid tissues (follicles) such as spleen lymph nodes tonsils and Peyer s patches[2] BCA-1/CXCL13 Protein Mouse (HEK293 Fc) is produced in HEK293 cells with a N-Terminal Fc-tag It consists of 88 amino acids (I22-A109)
Cayman Chemical ANTIBODY PerIplocIn 50mg
A cardiac glycoside with anticancer activity; increases viability and proliferation of CMECs at 2-50 µM; improves left ventricular structure and function in a rat model of chronic heart failure; inhibits cell proliferation in nine lung cancer cell lines (IC50s = 0.12-53 µM); induces apoptosis in SGC-7901 and MGC-803 gastric cancer cells and activates the ERK1/2-EGR1 pathway; reduces tumor growth in an HCC mouse xenograft model at 5 and 20 mg/kg; inhibits tumor growth in an A549 lung cancer mouse xenograft model at 50 and 100 UG
Cayman Chemical VU0469650hydrochlorIde 5mg
A negative allosteric mGluR1 modulator; inhibits glutamate-induced calcium flux in cells expressing human mGluR1 (IC50 = 99 nM); >100-fold selective for mGluR1 over mGluR2-8 at 10 µM
Broadpharm De-Boc-Docetaxel | 133524-69-3 | MFCD30182048 | 50 mg
De-Boc-Docetaxel | Purity: 95% | Mol Wt: 707.768 | 133524-69-3 | MFCD30182048 | 50 mg
Medkoo Biosciences Inc Mertansine | 139504-50-0 | MFCD28398157 | 25mg
Mertansine | Putity: > 98% | MW: 738.29 | 139504-50-0 | MFCD28398157 | 25mg
Cayman Chemical 11-DehydrocortIcosteron 5mg
An endogenous mineralocorticoid; increases Na+/K+-ATPase mRNA expression in vascular smooth muscle cells and inhibits aldosterone action in B. marinus toad bladder tissue in a concentration-dependent manner; decreases the sodium/creatine ratio and increases the potassium/creatine ratio in rat urine in a dose-dependent manner in a model of carbenoxolone-induced 11β-hydroxysteroid dehydrogenase inhibition; chronic administration increases plasma glucocorticoids levels, body weight gain, and adiposity, as well as induces insulin resistance in mice
Medchemexpress LLC Flecainide hydrochloride | 57415-44-8 | 99.9% | 450.80 | 50 MG
Flecainide hydrochloride is an orally active antiarrhythmic agent. It works by blocking sodium channels and inhibiting calcium ion release mediated by the cardiac ryanodine receptor (RyR2). This product is used in the research of diseases such as catecholaminergic polymorphic ventricular tachycardia (CPVT).
- Orally active antiarrhythmic agent
- Blocks sodium channels
- Inhibits calcium ion release mediated by cardiac ryanodine receptor (RyR2)
- Used in research for conditions like catecholaminergic polymorphic ventricular tachycardia (CPVT)
Medchemexpress LLC Benzeneethanol, 4-hydroxy- | 501-94-0 | 138.16 | 250 MG
Tyrosol is a derivative of phenethyl alcohol. It attenuates pro-inflammatory cytokines from cultured astrocytes and NF-κB activation, demonstrating anti-oxidative and anti-inflammatory effects.
- Attenuates pro-inflammatory cytokines from cultured astrocytes
- Attenuates NF-κB activation
- Exhibits anti-oxidative and anti-inflammatory effects
- Targets NF-κB and endogenous metabolite
- Research areas include inflammation/immunology
- Disease research fields include anti-aging
- Structurally classified as monophenols, phenols
- Sourced from microorganisms, plants, Canarium album (Lour.) Rauesch., Burseraceae
- Appears as a white to off-white solid
- Purity (HPLC) of 99.93%
- Water (KF) content is 0.07%
- Residue on ignition is 0.01%
- Consistent with structure by ¹H NMR spectrum
Medchemexpress LLC Antitubercular agent-30 | 384857-54-9 | C12H10N2O3S | 1 ML
Antitubercular agent-30 is an antibacterial agent effective against Mycobacterium tuberculosis with an MIC of 50 μg/mL. It exhibits minimal cytotoxic effect on murine macrophage cells, with an LD85 of approximately 100 μg/mL, and showed no cytotoxic effect on murine macrophages below 10 μg/mL when tested at concentrations between 0.1-100 μg/mL for 18 hours.
- Antibacterial agent
- Effective against Mycobacterium tuberculosis
- Minimal cytotoxic effect on murine macrophage cells
- MIC of 50 μg/mL
- LD85 of approximately 100 μg/mL
Selleck Chemical LLC Silybin E5670-5MG
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds Silybin induces apoptosis and exhibits hepatoprotective antioxidant anti-inflammatory anti-cancer activity
Selleck Chemical LLC cis-Bac430 E4958-100MG
Cis-Bac430 plays a role in mediating the movement of anti-tumor CD8 cells from the periphery to the tumor site thus enhancing the anti-tumor effect of an immune checkpoint inhibitor